Pub. Date : 2018 Sep
PMID : 29890224
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EP4 deficiency negatively regulate bile acid synthesis through repression of phosphorylated extracellular signal-regulated kinase 1/2 (ERK)-mediated cholesterol 7alpha-hydroxylase (CYP7A1) expression and that the hypercholesterolemia in EP4 knockout mice is due to a defect in cholesterol conversion into bile acids. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |