Title : Optimization of a Precolumn OPA Derivatization HPLC Assay for Monitoring of l-Asparagine Depletion in Serum during l-Asparaginase Therapy.

Pub. Date : 2018 Oct 1

PMID : 29878070






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1 And the corresponding derivative products were stable up to 19 h. The validated method had been successfully applied to monitor ASN depletion and l-aspartic acid, l-glutamine, l-glutamic acid levels in pediatric patients during l-asparaginase therapy. Glutamic Acid asparaginase and isoaspartyl peptidase 1 Homo sapiens