Pub. Date : 2018 Oct 1
PMID : 29873790
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 2 | We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 3 | We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 4 | We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 5 | Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 mug/kg dioxin did not survive beyond days 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 6 | Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality. | Dioxins | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |