Title : Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation.

Pub. Date : 2018

PMID : 29867510






1 Functional Relationships(s)
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1 Treatment with fluoxetine, a widely prescribed antidepressant, or SB203580, a p38-specific inhibitor, reversed the depressive-like behaviors, normalized the alterations in p-p38 and TNF-alpha levels and increased the levels of the anti-inflammatory cytokine IL-10 in the habenula. SB 203580 tumor necrosis factor Homo sapiens