Title : Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8⁺ T Cells from Feline Immunodeficiency Virus-Infected Cats.

Pub. Date : 2018 May 27

PMID : 29861472






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg interleukin 2 Homo sapiens
2 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg interleukin 2 Homo sapiens
3 We hypothesized that decreasing histone acetylation in virus-specific CD8+ T cells would decrease Treg-induced Foxp3 binding to the IL-2 promoter. treg interleukin 2 Homo sapiens