Title : Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction.

Pub. Date : 2018 Aug

PMID : 29859008






1 Functional Relationships(s)
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1 KEY RESULTS: With receptor affinities set to published values, the 2R-1T model satisfactorily characterized the interaction between noradrenaline and arginine-vasopressin in rat small mesenteric arteries (relative standard error <=20%), as well as the effect of phenoxybenzamine. Norepinephrine arginine vasopressin Rattus norvegicus