Pub. Date : 2018 Aug
PMID : 29858683
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |
| 2 | RESULTS: Sorafenib activated the Raf/MEK/ERK pathway and caused sorafenib resistance in HCC cell lines and patient-derived HCC primary cells. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |
| 3 | CONCLUSION: Reactivation of the Raf/MEK/ERK pathway through aberrant expression of RKIP is one of the mechanisms behind sorafenib resistance in HCC. | Sorafenib | zinc fingers and homeoboxes 2 | Homo sapiens |