Pub. Date : 2018 Aug
PMID : 29852353
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen gas inhibits lung cancer progression through targeting SMC3. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |
| 2 | Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |
| 3 | H2 translocated the subcellular location of SMC3 during cell division and decreased its stability and increased its ubiquitination in both A549 and H1975 cells. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |
| 4 | In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |
| 5 | In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |
| 6 | All data suggested that H2 inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer. | Hydrogen | structural maintenance of chromosomes 3 | Homo sapiens |