Title : Angptl2 deficiency attenuates paraquat (PQ)-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis through NF-κB pathway.

Pub. Date : 2018 Sep 3

PMID : 29852175






1 Functional Relationships(s)
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1 In vitro, we found that Angptl2 knockdown-suppressed inflammation, oxidative stress and fibrosis was restored by increasing NF-kappaB activation in PQ-incubated A549 cells; however, the results above were significantly reversed by inactivating NF-kappaB using its inhibitor, Bay 11-7085 or LY2409881. BAY 11-7085 angiopoietin-like 2 Mus musculus