Pub. Date : 2018
PMID : 29844932
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-kappaB signaling pathway. | cordycepin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling. | cordycepin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In addition to activating caspases, we show that, cordycepin prevents TNF-alpha-induced increase in CCL5, Akt, NF-kappaB, and c-FLIPL activation and that CCL5 siRNA could inhibit Akt/NF-kappaB signaling. | cordycepin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Thus, these results indicate that cordycepin inhibits CCL5-mediated Akt/NF-kappaB signaling, which upregulates caspase-3 activation in SKOV-3 cells, supporting the potential of cordycepin as a therapeutic agent for ovarian cancer. | cordycepin | AKT serine/threonine kinase 1 | Homo sapiens |