Title : Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

Pub. Date : 2018 Aug 15

PMID : 29844066






1 Functional Relationships(s)
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1 Furthermore, Sos1 disruption delayed the onset of tumor initiation, decreased tumor growth, and prevented malignant progression of papillomas in a DMBA (7,12-dimethylbenz[alpha]anthracene)/TPA (12-O-tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis model. 7,12-dimethylbenz[alpha]anthracene SOS Ras/Rac guanine nucleotide exchange factor 1 Mus musculus