Title : alpha 2-Adrenoceptors in the HT 29 human colon adenocarcinoma cell line: characterization with [3H]clonidine; effects on cyclic AMP accumulation.

Pub. Date : 1985 Jan 2

PMID : 2984004






2 Functional Relationships(s)
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1 When tested on intact cells, epinephrine, norepinephrine and clonidine were found to counteract, in a dose-dependent manner, the increase of cyclic AMP triggered by vasoactive intestinal peptide (VIP). Norepinephrine vasoactive intestinal peptide Homo sapiens
2 The physiological amines were the most efficient agonists: both epinephrine and norepinephrine inhibited VIP-induced cyclic AMP accumulation by 50-55% with KD values of 50 nM and 300 nM respectively. Norepinephrine vasoactive intestinal peptide Homo sapiens