Title : Enhanced follicle-stimulating hormone activity of deglycosylated human chorionic gonadotropin in ovarian granulosa cells.

Pub. Date : 1985 Jan

PMID : 2981077






6 Functional Relationships(s)
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1 When added with LH to FSH-treated cells, AHF-hCG inhibited LH-stimulated cAMP formation by 70% but did not alter the elevated level of progesterone production. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
2 When added to freshly prepared granulosa cells which have minimal LH receptors, AHF-hCG decreased FSH-stimulated cAMP production by 20% and reduced progesterone production by 50% and increased cGMP formation by 100% during 48 h of culture. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
3 In choleragen-treated granulosa cells, the increases in cAMP and progesterone synthesis were enhanced by addition of both hCG and AHF-hCG, and cGMP production was increased by AHF-hCG but slightly decreased by hCG. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
4 In choleragen-treated granulosa cells, the increases in cAMP and progesterone synthesis were enhanced by addition of both hCG and AHF-hCG, and cGMP production was increased by AHF-hCG but slightly decreased by hCG. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
5 In choleragen-treated granulosa cells, the increases in cAMP and progesterone synthesis were enhanced by addition of both hCG and AHF-hCG, and cGMP production was increased by AHF-hCG but slightly decreased by hCG. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
6 In choleragen-treated granulosa cells, the increases in cAMP and progesterone synthesis were enhanced by addition of both hCG and AHF-hCG, and cGMP production was increased by AHF-hCG but slightly decreased by hCG. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens