Title : The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior.

Pub. Date : 2018 May 24

PMID : 29795045






2 Functional Relationships(s)
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Protein Name
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1 The residue that plays a major role in determining the diverse pKa values of the proton shuttle is the one in position four, namely His for hCA II and Gly for hCA VII. Histidine carbonic anhydrase 2 Homo sapiens
2 These findings are in agreement with our previous studies that highlighted the importance of histidines on the protein surface of hCA II (among which His4) as crucial residues for the high catalytic efficiency of this isoform. Histidine carbonic anhydrase 2 Homo sapiens