Title : AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats.

Pub. Date : 2018 Nov 1

PMID : 29792868






4 Functional Relationships(s)
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1 AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus
2 More specifically, it remains to be ascertained whether AH6809 (an EP2 receptor antagonist) would interfere with the downstream of the PGE2, regulate the inflammatory mediators and improve neuronal damage in the hippocampus by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus
3 More specifically, it remains to be ascertained whether AH6809 (an EP2 receptor antagonist) would interfere with the downstream of the PGE2, regulate the inflammatory mediators and improve neuronal damage in the hippocampus by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus
4 AH6809 improves the recovery of injured neurons in the hippocampal CA1 area and downregulates the inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus