Title : The effect of elevated α1-acid glycoprotein on the pharmacokinetics of TAK-272 (SCO-272), an orally active renin inhibitor, in rats.

Pub. Date : 2019 May

PMID : 29790816






2 Functional Relationships(s)
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1 Following intravenous administration of TAK-272 to the turpentine-treated rats, the systemic clearance and volume of distribution decreased with the elevated plasma alpha1-acid glycoprotein (AGP) levels. Turpentine orosomucoid 1 Rattus norvegicus
2 Following intravenous administration of TAK-272 to the turpentine-treated rats, the systemic clearance and volume of distribution decreased with the elevated plasma alpha1-acid glycoprotein (AGP) levels. Turpentine orosomucoid 1 Rattus norvegicus