Title : Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia.

Pub. Date : 2018 Sep

PMID : 29773599






2 Functional Relationships(s)
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1 These suppressive effects of transforming growth factor beta1 on stromal cell functionality were abrogated by SD-208, an established inhibitor of transforming growth factor beta receptor signaling. SD-208 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens
2 Our findings establish transforming growth factor beta1 as a relevant trigger causing functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia and identify SD-208 as a candidate to revert these effects. SD-208 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens