Title : Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer.

Pub. Date : 2018

PMID : 29773061






2 Functional Relationships(s)
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1 Targeting mutant IDH by development of small molecule inhibitors is a rapidly emerging therapeutic approach as evidenced by the recent approval of the first selective mutant IDH2 inhibitor AG-221 (enasidenib) for the treatment of IDH2-mutated AML. enasidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Targeting mutant IDH by development of small molecule inhibitors is a rapidly emerging therapeutic approach as evidenced by the recent approval of the first selective mutant IDH2 inhibitor AG-221 (enasidenib) for the treatment of IDH2-mutated AML. enasidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens