Pub. Date : 2018 Aug 15
PMID : 29771357
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A promotive effect for halofuginone on membrane repair and synaptotagmin-7 levels in muscle cells of dysferlin-null mice. | halofuginone | dysferlin | Mus musculus |
| 2 | A hypo-osmotic shock assay on myotubes derived from wild-type (Wt) and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes. | halofuginone | dysferlin | Mus musculus |
| 3 | A hypo-osmotic shock assay on myotubes derived from wild-type (Wt) and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes. | halofuginone | dysferlin | Mus musculus |
| 4 | A hypo-osmotic shock assay on myotubes derived from wild-type (Wt) and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes. | halofuginone | dysferlin | Mus musculus |
| 5 | In laser-induced injury of isolated myofibers, halofuginone decreased the amount of FM1-43 at the injury site of dysf-/- myofibers while having no effect on Wt myofibers. | halofuginone | dysferlin | Mus musculus |
| 6 | These results implicate halofuginone in ameliorating muscle-cell membrane integrity in dysf-/- mice. | halofuginone | dysferlin | Mus musculus |
| 7 | Halofuginone increased lysosome scattering across the cytosol of dysf-/- primary myoblasts, in a protein kinase/extracellular signal-regulated protein kinase and phosphoinositide 3 kinase/Akt-dependent manner, in agreement with an elevation in lysosomal exocytotic activity in these cells. | halofuginone | dysferlin | Mus musculus |
| 8 | While halofuginone did not affect patch-repair-complex key proteins, it further enhanced Syt-7 levels and its spread across the cytosol in dysf-/- myofibers and muscle tissue, and increased its co-localization with lysosomes. | halofuginone | dysferlin | Mus musculus |