Pub. Date : 2018 Apr 20
PMID : 29765517
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the mevalonate pathway by statins, inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), resulted in reduced expression of FoxM1 and increased cell death in human hepatoma cells. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Inhibition of the mevalonate pathway by statins, inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), resulted in reduced expression of FoxM1 and increased cell death in human hepatoma cells. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | Re-exposure of mevalonate, a product of HMGCR, restored these effects. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 4 | Likewise, knockdown of HMGCR reduced FoxM1 expression, indicating that FoxM1 expression was regulated by the mevalonate pathway in HCC. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 5 | In surgically resected human HCC tissues, the gene expression of FoxM1 had a positive correlation with that of the mevalonate pathway-related genes, such as HMGCR or sterol regulatory element-binding protein 2 (SREBP2). | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 6 | Furthermore, the gene expression of FoxM1 along with that of HMGCR or SREBP2 defined prognosis of HCC patients, suggesting the clinical significance of the mevalonate-FoxM1 pathway in human HCC. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |