Pub. Date : 2018 Jul
PMID : 29763644
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats. | Celecoxib | toll-like receptor 4 | Rattus norvegicus |
| 2 | In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways. | Celecoxib | toll-like receptor 4 | Rattus norvegicus |
| 3 | In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways. | Celecoxib | toll-like receptor 4 | Rattus norvegicus |
| 4 | When the CCX group was compared to the KA group, there was also a significant decrease in the number of HMGB1 and TLR-4 transcripts (p < 0.05) and in COX-2 protein expression (p < 0.05) in the most important areas for seizure generation (the hippocampus and cortex) at both the early and late time points. | Celecoxib | toll-like receptor 4 | Rattus norvegicus |