Title : Attenuation of macrophage accumulation and polarisation in obese diabetic mice by a small molecule significantly improved insulin sensitivity.

Pub. Date : 2018 Jun 27

PMID : 29763604






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Administration of dmp markedly increased SIRT1 level by inducing its gene expression with a consequent decrease in macrophage population. Unithiol sirtuin 1 Mus musculus
2 In addressing the question about how dmp induced excess SIRT1 could reduce MCP1, FetA and IFNgamma levels, we found that it was due to the inactivation of NFkappaB because of its deacetylation by SIRT1. Unithiol sirtuin 1 Mus musculus
3 In addressing the question about how dmp induced excess SIRT1 could reduce MCP1, FetA and IFNgamma levels, we found that it was due to the inactivation of NFkappaB because of its deacetylation by SIRT1. Unithiol sirtuin 1 Mus musculus