Title : Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells.

Pub. Date : 2018 May 31

PMID : 29754474






1 Functional Relationships(s)
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1 Pre-treatment with Z-VAD-fmk, JNK inhibitor SP600125 and N-acetyl-l-cysteine (NAC), a ROS scavenger, partly improved the survival rates and restored OMT-induced cellular damage, and reduced caspase-3 cleavage. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 3 Homo sapiens