Title : Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone.

Pub. Date : 2018 Jul

PMID : 29753783






2 Functional Relationships(s)
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1 Further, the expression of autophagy-related genes, such as Beclin1 and LC3, were up-regulated after nicotine exposure (P < 0.05). Nicotine microtubule-associated protein 1 light chain 3 alpha Mus musculus
2 Moreover, immunofluorescent staining of LC3 in the TM3 Leydig cell line indicated that rapamycin and nicotine exposure up-regulates the autophagy phenotype/process and down-regulates their testosterone synthesis. Nicotine microtubule-associated protein 1 light chain 3 alpha Mus musculus