Title : Glycine Transporter-1 and glycine receptor mediate the antioxidant effect of glycine in diabetic rat islets and INS-1 cells.

Pub. Date : 2018 Aug 1

PMID : 29753073






2 Functional Relationships(s)
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1 Glycine transporter-1 inhibitor blocked the antioxidative effect of glycine by reducing the intracellular GSH content, and glycine receptor inhibitor reversed the glycine antioxidative effect by blocking p22phox. Glycine solute carrier family 6 member 9 Rattus norvegicus
2 Collectively, our findings reveal a mechanism by which glycine protects diabetic beta-cells against damage caused by oxidative stress by increasing glycine transporter-1-mediated synthesis of GSH and by reducing glycine receptor-mediated ROS production. Glycine solute carrier family 6 member 9 Rattus norvegicus