Pub. Date : 2018 Jul 3
PMID : 29750510
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Bioactivated aflatoxin B1 was reacted with a 32 bp exon 7 fragment of the p53 gene using eight microsomal cytochrome (cyt) P450 enzymes from different organs coated on magnetic beads. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
2 | This is the first demonstration in a cell-free medium that the aflatoxin B1 metabolite selectively causes abasic site formation and strand breaks at codon 249 of the p53 probe, corresponding to the chemical pathway and mutations of p53 in human liver cells and tumors. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
3 | This is the first demonstration in a cell-free medium that the aflatoxin B1 metabolite selectively causes abasic site formation and strand breaks at codon 249 of the p53 probe, corresponding to the chemical pathway and mutations of p53 in human liver cells and tumors. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |