Pub. Date : 2019 May
PMID : 29735980
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1). | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1). | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | Interestingly, this inhibition of CYP2E1 expression did not occur in unfasted Opn-/- mice, but was significant in fasted Opn-/- mice and maintained for 2 hours after APAP challenge in fasted Opn-/- mice. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |