Pub. Date : 2018 May
PMID : 29719454
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans. | Rosuvastatin Calcium | BCR pseudogene 1 | Homo sapiens |
| 2 | Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. | Rosuvastatin Calcium | BCR pseudogene 1 | Homo sapiens |
| 3 | Our PBPK model demonstrated that the major causes of increase in rosuvastatin exposure are mediated by intestinal BCRP (rosuvastatin-telmisartan interaction) or by both of BCRP and OATP1B1/3 (rosuvastatin-cyclosporine interaction). | Rosuvastatin Calcium | BCR pseudogene 1 | Homo sapiens |
| 4 | Our PBPK model demonstrated that the major causes of increase in rosuvastatin exposure are mediated by intestinal BCRP (rosuvastatin-telmisartan interaction) or by both of BCRP and OATP1B1/3 (rosuvastatin-cyclosporine interaction). | Rosuvastatin Calcium | BCR pseudogene 1 | Homo sapiens |