Pub. Date : 2018 Oct
PMID : 29710396
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Second, TM and another copper chelator, bathocuproine sulfonate (BCS), promoted nonamyloidogenic processing of AbetaPP via inducing the expression of ADAM10 and the secretion of sAbetaPPalpha. | Copper | a disintegrin and metallopeptidase domain 10 | Mus musculus |
| 2 | Third, the inducible ADAM10 production caused by copper chelators can be blocked by a melatonin receptor (MT1/2 ) antagonist (luzindole) and a MT2 inhibitor (4-P-PDOT), suggesting that the expression of ADAM10 depends on the activation of MT1/2 signaling pathways. | Copper | a disintegrin and metallopeptidase domain 10 | Mus musculus |
| 3 | Third, the inducible ADAM10 production caused by copper chelators can be blocked by a melatonin receptor (MT1/2 ) antagonist (luzindole) and a MT2 inhibitor (4-P-PDOT), suggesting that the expression of ADAM10 depends on the activation of MT1/2 signaling pathways. | Copper | a disintegrin and metallopeptidase domain 10 | Mus musculus |
| 4 | Based on these results, we conclude that copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways. | Copper | a disintegrin and metallopeptidase domain 10 | Mus musculus |