Title : Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress.

Pub. Date : 2018 Apr 21

PMID : 29690507






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The compound APR-246 (PRIMA-1MET) is a known reactivator of (mutant) p53 and inducer of oxidative stress which can sensitize cancer cells to platinum-based chemotherapeutics. Platinum tumor protein p53 Homo sapiens