Pub. Date : 1988 Jul
PMID : 2968844
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IL-1-containing supernatants from drug-treated macrophages at dilutions of up to 1:32 resulted in enhanced thymocyte proliferation compared to control, non-drug-treated cultures and contained less than 2 ng/ml of PGE2. | Dinoprostone | interleukin 1 complex | Mus musculus |
| 2 | Exogenous PGE2, in the concentration range produced in macrophage supernatants (10-20 ng/ml), directly inhibited IL-1-stimulated thymocyte proliferation. | Dinoprostone | interleukin 1 complex | Mus musculus |
| 3 | Finally, when macrophages were stimulated with LPS for 24 hr in the presence of added PGE2, thymocyte proliferation was inhibited at the lowest supernatant dilutions, but as the IL-1-containing supernatants were diluted out, the assay curves were indistinguishable from non-PGE2-treated control. | Dinoprostone | interleukin 1 complex | Mus musculus |