Pub. Date : 2018 May
PMID : 29685624
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells. | Folic Acid | Janus kinase 2 | Homo sapiens |
| 2 | Folic acid targeted the activation of Janus kinase 2, downregulated the phosphorylation of signal transducer and activator of transcription 3, and decreased the expression of nuclear factor-kappaB p65 protein in cells. | Folic Acid | Janus kinase 2 | Homo sapiens |
| 3 | In conclusion, folic acid efficiently inhibited the inflammatory response of THP-1 cells under hypoxic conditions by inhibiting reactive oxygen species production and the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. | Folic Acid | Janus kinase 2 | Homo sapiens |