Pub. Date : 2018
PMID : 29681856
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine. | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 2 | TAAR1 is involved in the effects of addictive drugs, such as amphetamines, cocaine and ethanol, but the impact of TAAR1 on the effects of nicotine, the psychoactive drug responsible for the development and maintenance of tobacco smoking, has not yet been studied. | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 3 | This study was performed to investigate the possible modulatory action of TAAR1 on the effects of nicotine on locomotor behaviors in rats and mice. | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 4 | Pretreatment with the TAAR1 agonist RO5263397 dose-dependently decreased nicotine-induced hyperlocomotion in rats habituated to locomotor boxes, prevented the development of nicotine sensitization and blocked hypermotility in nicotine-sensitized rats at the highest tested dose (10 mg/kg). | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 5 | Pretreatment with the TAAR1 agonist RO5263397 dose-dependently decreased nicotine-induced hyperlocomotion in rats habituated to locomotor boxes, prevented the development of nicotine sensitization and blocked hypermotility in nicotine-sensitized rats at the highest tested dose (10 mg/kg). | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 6 | Pretreatment with the TAAR1 agonist RO5263397 dose-dependently decreased nicotine-induced hyperlocomotion in rats habituated to locomotor boxes, prevented the development of nicotine sensitization and blocked hypermotility in nicotine-sensitized rats at the highest tested dose (10 mg/kg). | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 7 | Based on the results of the present study, TAAR1 activation attenuates the locomotion-stimulating effects of nicotine on rats. | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |
| 8 | Further studies aimed at analyzing the effects of TAAR1 agonists on animal models of nicotine addiction are warranted. | Nicotine | trace-amine-associated receptor 1 | Rattus norvegicus |