Title : Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.

Pub. Date : 2018 Apr 20

PMID : 29678208






4 Functional Relationships(s)
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Protein Name
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1 IL-1beta induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). Dinoprostone interleukin 1 beta Rattus norvegicus
2 IL-1beta induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). Dinoprostone interleukin 1 beta Rattus norvegicus
3 CONCLUSIONS: Glial IL-1beta upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1beta/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. Dinoprostone interleukin 1 beta Rattus norvegicus
4 CONCLUSIONS: Glial IL-1beta upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1beta/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. Dinoprostone interleukin 1 beta Rattus norvegicus