Title : Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein.

Pub. Date : 2018 Jun

PMID : 29675746






2 Functional Relationships(s)
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1 MDR cells accumulated twice as much cabazitaxel than docetaxel, and these levels could be restored to parental levels in the presence of the P-gp inhibitor PSC-833 (valspodar). Docetaxel phosphoglycolate phosphatase Homo sapiens
2 One cell model expressing low levels of P-gp was not cross-resistant to cabazitaxel while demonstrating modest resistance to docetaxel. Docetaxel phosphoglycolate phosphatase Homo sapiens