Pub. Date : 2018 Apr 24
PMID : 29669753
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ibrutinib has previously been shown to inhibit Bruton"s tyrosine kinase (BTK) and interleukin-2-inducible T-cell kinase (ITK), which mediate B-cell and T-cell receptor signaling, respectively. | ibrutinib | IL2 inducible T cell kinase | Homo sapiens |
| 2 | Ibrutinib has previously been shown to inhibit Bruton"s tyrosine kinase (BTK) and interleukin-2-inducible T-cell kinase (ITK), which mediate B-cell and T-cell receptor signaling, respectively. | ibrutinib | IL2 inducible T cell kinase | Homo sapiens |
| 3 | Whether ibrutinib inhibition of ITK can lead to clinical response in T-cell malignancies is unknown. | ibrutinib | IL2 inducible T cell kinase | Homo sapiens |
| 4 | We hypothesized that ibrutinib-mediated ITK inhibition in T-cell lymphoma would result in decreased signaling through the T-cell receptor pathway and promote antitumor immune response by driving selective cytotoxic Th1 CD4 effector T-cell differentiation. | ibrutinib | IL2 inducible T cell kinase | Homo sapiens |
| 5 | Our data suggest that ibrutinib inhibition of ITK has limited clinical activity in T-cell lymphoma. | ibrutinib | IL2 inducible T cell kinase | Homo sapiens |