Title : Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors.

Pub. Date : 2018 Jul

PMID : 29669164






2 Functional Relationships(s)
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1 Galantamine (10 nM to 100 muM) was evaluated for direct agonist effects and for positive modulation by co-application with sub-maximally efficacious concentrations of ACh. Galantamine latexin Homo sapiens
2 At concentrations from 10 muM and above, galantamine inhibited the activity with a mechanism of action consistent with open-channel pore blockade at all receptor types. Galantamine latexin Homo sapiens