Pub. Date : 2018 May 28
PMID : 29668854
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 2 | We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 3 | We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 4 | We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 5 | The present study used cellular models of prostate cancer and archived plasma/adenocarcinoma tissues and sections from the TRAMP study to demonstrate inhibition of fatty acid synthesis by SFN treatment in vitro and in vivo. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 6 | Immunohistochemistry revealed a significant decrease in expression of FASN and ACC1 proteins in prostate adenocarcinoma sections of SFN-treated TRAMP mice when compared with controls. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 7 | SFN administration to TRAMP mice resulted in a significant decrease in plasma and/or prostate adenocarcinoma levels of total free fatty acids, total phospholipids, acetyl-CoA and ATP. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 8 | Consistent with these results, number of neutral lipid droplets was lower in the prostate adenocarcinoma sections of SFN-treated TRAMP mice than in control tumors. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |
| 9 | Collectively, these observations indicate that prostate cancer chemoprevention by SFN in TRAMP mice is associated with inhibition of fatty acid metabolism. | sulforaphane | tumor necrosis factor receptor superfamily, member 25 | Mus musculus |