Pub. Date : 2019 Jan
PMID : 29665128
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thus, we seek to establish what role Abeta plays in kainic acid-induced toxicity using in vivo and in vitro paradigms. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 2 | Our results show that systemic injection of kainic acid to adult rats triggers seizures, gliosis and loss of hippocampal neurons, along with increased levels/processing of amyloid precursor protein (APP), resulting in the enhanced production of Abeta-related peptides. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 3 | Our results show that systemic injection of kainic acid to adult rats triggers seizures, gliosis and loss of hippocampal neurons, along with increased levels/processing of amyloid precursor protein (APP), resulting in the enhanced production of Abeta-related peptides. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 4 | The changes in APP levels/processing were evident primarily in activated astrocytes, implying a role for astrocytic Abeta in kainic acid-induced toxicity. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 5 | Accordingly, we showed that treating rat primary cultured astrocytes with kainic acid can lead to increased Abeta production/secretion without any compromise in cell viability. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 6 | Additionally, we revealed that kainic acid reduces neuronal viability more in neuronal/astrocyte co-cultures than in pure neuronal culture, and this is attenuated by precluding Abeta production. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |
| 7 | Collectively, these results indicate that increased production/secretion of Abeta-related peptides from activated astrocytes can contribute to neurotoxicity in kainic acid-treated rats. | Kainic Acid | amyloid beta precursor protein | Rattus norvegicus |