Title : A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors.

Pub. Date : 2018 May 1

PMID : 29664021






1 Functional Relationships(s)
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1 We identified a specific bioactive hyaluronan fragment (bHAf) that downregulates myelin gene expression and chronically blocks OPC maturation and myelination via a tolerance-like mechanism that dysregulates pro-myelination signaling via AKT. Hyaluronic Acid AKT serine/threonine kinase 1 Homo sapiens