Title : Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate.

Pub. Date : 2018 Apr 16

PMID : 29662077






1 Functional Relationships(s)
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1 Importantly, inhibition of mutant IDH1 may lead to the reprogramming of tumor metabolism, suggested by simultaneous changes in glutathione, glutamine, glutamate, and lactate. Lactic Acid isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens