Title : Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio).

Pub. Date : 2018 Jul

PMID : 29626809






3 Functional Relationships(s)
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1 Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio). Chlorpyrifos v-fos FBJ murine osteosarcoma viral oncogene homolog Ab Danio rerio
2 The aim of the present study is to investigate the toxicity effects of frequently used pesticides, involving cypermethrin, deltamethrin, chlorpyrifos and imidacloprid, on the expression of bdnf and c-fos genes in zebrafish brain tissues. Chlorpyrifos v-fos FBJ murine osteosarcoma viral oncogene homolog Ab Danio rerio
3 These results showed that the exposure to the acute cypermethrin, deltamethrin, chlorpyrifos and imidacloprid intoxication disrupted the normal neuronal activity, resulting in neurotoxic effect, also DNA-binding Increasing c-fos activation, an oncoprotein from the family of the Nuclear Proteins, is also true of the knowledge that these chemicals are oncogenic in zebrafish brain tissues. Chlorpyrifos v-fos FBJ murine osteosarcoma viral oncogene homolog Ab Danio rerio