Title : Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease.

Pub. Date : 2018 Aug

PMID : 29624734






2 Functional Relationships(s)
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1 We found that iron accumulation in MPSIIIB mice primarily affected the cerebral cortex where hepcidin levels were higher than in wild-type mice, and increased with aging. Iron hepcidin antimicrobial peptide Mus musculus
2 Hepcidin induction results from activation of the TLR4 pathway and STAT3 signaling, and leads to iron retention within microglia. Iron hepcidin antimicrobial peptide Mus musculus