Pub. Date : 2018
PMID : 29619114
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. | dehydroacetic acid | microRNA 16-1 | Homo sapiens |
| 2 | Here, we investigated whether in vitro concentrations of DHA equal to human plasma levels, are able to modulate, Wt-p53, survivin, and microRNA-16-1 in CRC cells with stem cell-like properties. | dehydroacetic acid | microRNA 16-1 | Homo sapiens |
| 3 | Treatment with 100 and 150 muM/L DHA increased microRNA-16-1 expression levels by 1.3- to 1.7-fold and enhanced the microRNA-16-1/survivin mRNA, p53/survivin, and caspase-3/survivin protein ratios by 1.7- to 1.8-, 1.3- to 2.6-, and 1.3- to 2-fold increases respectively. | dehydroacetic acid | microRNA 16-1 | Homo sapiens |
| 4 | Treatment with 100 and 150 muM/L DHA increased microRNA-16-1 expression levels by 1.3- to 1.7-fold and enhanced the microRNA-16-1/survivin mRNA, p53/survivin, and caspase-3/survivin protein ratios by 1.7- to 1.8-, 1.3- to 2.6-, and 1.3- to 2-fold increases respectively. | dehydroacetic acid | microRNA 16-1 | Homo sapiens |
| 5 | Conclusion: Wt-p53, survivin, and microRNA-16-1 appear to be promising molecular targets of DHA. | dehydroacetic acid | microRNA 16-1 | Homo sapiens |