Title : Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities.

Pub. Date : 2018

PMID : 29613828

1 Functional Relationships(s)
Compound Name
Protein Name
1 TNF-alpha induced mitochondrial dysfunction with impaired basal, ATP-linked, and maximal respiration, decreased cellular ATP synthesis, and increased mitochondrial superoxide production (measured by MitoSOX red fluorescence), which were rescued by inhibiting HDACs with MPT0E014 (1 muM, a Class I and IIb inhibitor), or MS-275 (1 muM, a Class I inhibitor). Superoxides tumor necrosis factor Homo sapiens