Pub. Date : 2018 May
PMID : 29604179
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the yeast Saccharomyces cerevisiae Aft1, the low iron-sensing transcription factor is known to regulate the expression of the FET3 gene. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 2 | We suggest that the activation of FET3 by Ace1 prevents the hyper activation of Aft1, possibly by assuring the adequate functioning of mitochondrial iron-sulfur cluster biogenesis. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 3 | While reinforcing the link between iron and copper homeostasis, this work unveils a novel protection mechanism against copper toxicity mediated by Ace1, which relies in the activation of FET3 and results in the restriction of Aft1 activity as a means to prevent excessive copper accumulation. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |