Title : 3'-Formyl phosphate-ended DNA: high-energy intermediate in antibiotic-induced DNA sugar damage.

Pub. Date : 1987 Oct

PMID : 2959956






2 Functional Relationships(s)
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1 From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5". aminoxyl complement C5 Homo sapiens
2 From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5". aminoxyl complement C5 Homo sapiens