Title : Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.

Pub. Date : 2018 Jun 1

PMID : 29579237






1 Functional Relationships(s)
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1 Inhibition of acid ceramidase by carmofur resulted in increased ceramide levels and decreased glucosylsphingosine levels in GCase-deficient cells, and also reduced oxidized alpha-synuclein and levels of ubiquitinated proteins in GBA1-PD patient-derived dopaminergic neurons. sphingosyl beta-glucoside N-acylsphingosine amidohydrolase 1 Homo sapiens