Title : Differences in α-Crystallin isomerization reveal the activity of protein isoaspartyl methyltransferase (PIMT) in the nucleus and cortex of human lenses.

Pub. Date : 2018 Jun

PMID : 29571628






2 Functional Relationships(s)
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Protein Name
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1 Interestingly, the abundance of L-isoAsp is low in the water-soluble cortex despite being the dominant product generated by isomerization of Asp in vitro, suggesting that Protein L-isoaspartyl methyltransferase (PIMT) is active in the cortex and suppresses the accumulation of L-isoAsp. Aspartic Acid protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens
2 Interestingly, the abundance of L-isoAsp is low in the water-soluble cortex despite being the dominant product generated by isomerization of Asp in vitro, suggesting that Protein L-isoaspartyl methyltransferase (PIMT) is active in the cortex and suppresses the accumulation of L-isoAsp. Aspartic Acid protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens