Title : MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF-κB signaling pathway in breast cancer.

Pub. Date : 2018 Jun

PMID : 29567542






9 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-212) in doxorubicin (DOX)-resistant and -sensitive breast cancer tumors and cells. Doxorubicin microRNA 132 Homo sapiens
2 Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-212) in doxorubicin (DOX)-resistant and -sensitive breast cancer tumors and cells. Doxorubicin microRNA 132 Homo sapiens
3 Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-212) in doxorubicin (DOX)-resistant and -sensitive breast cancer tumors and cells. Doxorubicin microRNA 132 Homo sapiens
4 Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-212) in doxorubicin (DOX)-resistant and -sensitive breast cancer tumors and cells. Doxorubicin microRNA 132 Homo sapiens
5 We found that miR-132/-212 were commonly overexpressed in DOX-resistant breast cancer tumors and cells. Doxorubicin microRNA 132 Homo sapiens
6 Silenced miR-132/-212 expression induced DOX accumulation in MCF-7/ADR cells, while overexpression of miR-132/-212 led to breast cancer resistance protein (BCRP)-based DOX efflux in MCF-7 cells. Doxorubicin microRNA 132 Homo sapiens
7 Silenced miR-132/-212 expression induced DOX accumulation in MCF-7/ADR cells, while overexpression of miR-132/-212 led to breast cancer resistance protein (BCRP)-based DOX efflux in MCF-7 cells. Doxorubicin microRNA 132 Homo sapiens
8 Silenced miR-132/-212 expression induced DOX accumulation in MCF-7/ADR cells, while overexpression of miR-132/-212 led to breast cancer resistance protein (BCRP)-based DOX efflux in MCF-7 cells. Doxorubicin microRNA 132 Homo sapiens
9 Down-regulation of miR-132/-212 sensitized MCF-7/ADR cells to DOX. Doxorubicin microRNA 132 Homo sapiens